Compound status: 
Historic compound: While this compound has been used to interrogate specific protein targets, it is not a chemical probe and should not be used in assays that depend on a potent and selective modulator of the protein.
Note about activity: 

Broad specificity kinase inhibitor: Tozasertib binds many kinases in addition to the primary target that are not in the same subgroup as the primary target (Selectivity score [Kd off-target/Kd primary target]=0.0314). Karaman et al., 2008. Nat. Biotech. 26, 127-132.

Probe Information