Compound status: 
Historic compound: While this compound has been used to interrogate specific protein targets, it is not a chemical probe and should not be used in assays that depend on a potent and selective modulator of the protein.
Note about activity: 

Intended target: HHAT; RUSKI-43 inhibited reporter signal under Shh (and HHAT)-independent conditions, and RUSKI-43 is cytotoxic to Shh-Light2 cells, which do not depend on Shh signaling for their survival (EC50=11 uM).

Probe Information