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up to 1 uM
up to 5 uM
1H NMR: (DMSO-d6, 400 MHz) δppm 7.83 (d, J = 7.7 Hz, 1 H), 7.75–7.67 (m, 1 H), 7.60–7.49 (m, 2 H), 7.42–7.35 (m, 1 H), 7.33–7.27 (m, 1 H), 6.58 (s, 1 H), 2.19 (br s, 3 H).
RU.521 did not show any significant inhibition of reporter activity which is distinct from its activities in cells exposed to dsDNA when cGAS is present.