Compound status: 
Historic compound: While this compound has been used to interrogate specific protein targets, it is not a chemical probe and should not be used in assays that depend on a potent and selective modulator of the protein.
Note about activity: 

Intended target: MDM2, Nutlins were the first small molecule antagonists of MDM2 reported (PMID: 14704432) but they have been superceded by more potent molecules (PMID: 25396320).

Mechanism of action: 

Probe Information