Nutlin-2
Compound status:
Historic compound: While this compound has been used to interrogate specific protein targets, it is not a chemical probe and should not be used in assays that depend on a potent and selective modulator of the protein.Note about activity:
Intended target: MDM2, Nutlins were the first small molecule antagonists of MDM2 reported (PMID: 14704432) but they have been superceded by more potent molecules. (PMID: 25396320).
Mechanism of action:
Antagonist
