November 1, 2021

The new Chemical Probes Portal has now moved to including data and recommendations on more than 650 small molecule tools.The new Portal now has a faster, more intuitive search, easier online forms for submitting and reviewing compounds and an entirely new backend structure to facilitate updates in the future. This site will be available for a short time, but we are no longer updating the information. Please get in touch if there are features of this site that you require so that we can integrate them into the new system.

September 15, 2021

Alle Dinge sind Gift, und nichts ist ohne Gift, allein die Dosis macht dass ein Ding kein Gift ist. (The dose makes the poison.)

Aled Edwards, CEO of the Structural Genomics Consortium.

August 12, 2021

Since the establishment of the Portal (1) we have provided guidelines on criteria for chemical probes that are aimed for use in cellular models and that would apply also for use in organismal models in conditions equivalent to cell culture, for example zebra fish embryos.

But for application in species such as the mouse and rat – the most commonly used in biomedical research – there are further hoops that chemical probes must jump through.

July 20, 2021

Have you tested the new Portal site yet? We're creating a new home for the Chemical Probes Portal, which makes it easier than ever to get quality information about small molecule inhibitors and other chemical tools and to find expert recommendations on these. 

Head to for a faster search, a dedicated information centre about chemical probes, and an online probe submission form.

March 5, 2021

Ten outstanding compounds that joined the Portal in 2020.

October 11, 2020

Chemical Probes, small molecules designed to specifically modulate protein functions, are useful tools to study biological processes. PROTACS are hybrid molecule chimera which comprise a ligand and a peptide recognition motif for an E3 ligase. One side is targeting the protein of interest, the other draws in the target protein for ubiquitination and destruction by the proteasome.

August 10, 2020

Both the Chemical Probes Portal and the Probe Miner resource have been recommended in an excellent new review in Nature Reviews Genetics on the topic of discovering and validating gene dependencies in cancer cells.

June 30, 2020

Chemical Probes mentioned in the Editorial of Expert Opinion on Drug Discovery @tandfnewsroom

as "Excellent web resource for chemical probes and information" check it out here

June 19, 2020

To mark its fifteenth anniversary, the latest issue of Nature Chemical Biology (Volume 16 Issue 6, June 2020) has named a selection of papers they describe as their ‘Greatest Hits’ over the last five years.

We feel honoured that one of the selected papers is the Arrowsmith et al Commentary that highlighted the ‘promise and perils of chemical probes’ and announced the launch of the Chemical Probes Portal — described as a ‘a community-driven wiki resource to improve quality and convey current best practice.’