Maritoclax

Compound status: 
Historic compound: While this compound has been used to interrogate specific protein targets, it is not a chemical probe and should not be used in assays that depend on a potent and selective modulator of the protein.
Note about activity: 

Intended target=MCL1; Maritoclax is a natural product that was reported as a BH3 mimetic specific for MCL1 (https://www.ncbi.nlm.nih.gov/pubmed/22311987). Subsequent studies have challenged maritoclax’s selectivity for MCL1 over other BCL2 proteins (https://www.ncbi.nlm.nih.gov/pubmed/24157874, https://www.ncbi.nlm.nih.gov/pubmed26059440) and reported additional cellular targets (https://www.ncbi.nlm.nih.gov/pubmed/28154844).

Probe Information