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Historic compound: While this compound has been used to interrogate specific protein targets, it is not a chemical probe and should not be used in assays that depend on a potent and selective modulator of the protein.
Note about activity:
Non selective compound, pan-active against multiple demethylases. Intended target: Jumonji protein demethylases. JIB-04 is a fragment that contains a promiscuous methylene hydrazine group. While chelation to metals by probes is okay depending on context, some degree of specificity is desired. JIB-04 lacks such specificity.