GT949

Protein target name:

SLC1A2

Mechanism of action:

Noncompetitive Positive Allosteric Modulator

Recommended Concentration for use in cells:

up to 10 uM

Probe Availability

MedChemExpress

TOCRIS

Probe Information

Target and Probe Information

Target Details

Target class:

Other

Define other target class:

Solute Transporter Proteins

Subclass:

SLC Family

HUGO ID:

HGNC:10940

Entrez gene ID:

6506

UNIPROT ID:

P43004

Target alias:

HBGT; DEE41; EAAT2; GLT-1; EIEE41

Probe Details

Chemical Probes Portal ID:

CPP2301

PubChem CID:

3195790

SMILES string:

O=C1NC2=C(C=C(OC)C=C2)C=C1C(N3CCN(C4CCCCC4)CC3)C5=NN=NN5CCC6=CC=CC=C6

InChi Key:

ZVWPOIUAPXDLMB-UHFFFAOYSA-N

Control compound:

GT996

Validation in Cells and Model Organisms

In cell validation

On target activity in cells

Potency in cells:

EC50

0.041 nM

Potency assay (cells):

EEAT2-mediated glutamate update assay

Off target activity in cells

Probe Selectivity in Cell:

GT949 demonstrated selectivity to EAAT2 and had no effect on glutamate activity mediated by EAAT1 or EAAT3.

Outside Target Family: Exhibits no significant effect on DAT, SERT and NET or NMDA receptors

Primary Reference

Reference (doi):

10.1021/acschemneuro.7b00308 10.1021/acschemneuro.9b00061

Reference (PMID):

29140675 31257852

GT949

Probe Availability

Probe Information

Target Details

HBGT; DEE41; EAAT2; GLT-1; EIEE41

Probe Details

In cell validation

Primary Reference

Supporting Organizations

Interested in supporting the portal?

Search form

GT949

Probe Availability

Probe Information

Target Details

HBGT; DEE41; EAAT2; GLT-1; EIEE41

Probe Details

In cell validation

Primary Reference

Supporting Organizations

Interested in supporting the portal?