Gossypol

Compound status: 
Historic compound: While this compound has been used to interrogate specific protein targets, it is not a chemical probe and should not be used in assays that depend on a potent and selective modulator of the protein.
Note about activity: 

Intended target: BCL2; Gossypol has multiple reported mechanims of action, including agonizing phospholipase A2 and induction of NOXA; Soderquist & Eastman. BCL2 inhibitors as anticancer drugs: a plethora of misleading BH3 mimetics. Mol Cancer Ther. 15, 2011-7 (2016).

Probe Information