Garcinol

Compound status: 
Historic compound: While this compound has been used to interrogate specific protein targets, it is not a chemical probe and should not be used in assays that depend on a potent and selective modulator of the protein.
Note about activity: 

Intended target=KAT2B, EP300 (PCAF, p300); Garcinol has low potency for PCAF and p300 in biochemical assays (IC50=5 uM and 7 um, respectively); Balasubramanyam et al., Polyisoprenylated benzophenone, garcinol, a natural histone acetyltransferase inhibitor, represses chromatin transcription and alters global gene expression. J Biol Chem. 279, 33716-26 (2004).

Probe Information