Diflusinal
Compound status:
Historic compound: While this compound has been used to interrogate specific protein targets, it is not a chemical probe and should not be used in assays that depend on a potent and selective modulator of the protein.Note about activity:
Intended target=EP300, CREBBP (p300/CBP); this compound is weakly potent (IC50 ~1 mM) against these targets in biochemical assays. It is not a chemical probe. Shirakawa et al., Salicylate, diflunisal and their metabolites inhibit CBP/p300 and exhibit anticancer activity. Elife. 5, pii: e11156 (2016).
