Brusatol

Compound status:

Historic compound: While this compound has been used to interrogate specific protein targets, it is not a chemical probe and should not be used in assays that depend on a potent and selective modulator of the protein.

Note about activity:

Intended target=Keap1-Nrf2 antioxidant response pathway; found to be a global protein synthesis inhibitor; Vartanian et al., Application of Mass Spectrometry Profiling to Establish Brusatol as an Inhibitor of Global Protein Synthesis. Mol. Cell. Proteomics 15, 1220-31 (2015).

Probe Information

Target and Probe Information

Target Details

Probe Details

Chemical Probes Portal ID:

CPP1434

Probe alias:

Yatansin, NSC 172924, BRN 1444847, AK128303

PubChem CID:

73432

SMILES string:

CC1=C(C(=O)C[C@]2([C@H]1C[C@@H]3[C@]45[C@@H]2[C@H]([C@@H]([C@]([C@@H]4[C@H](C(=O)O3)OC(=O)C=C(C)C)(OC5)C(=O)OC)O)O)C)O

InChi Key:

ZZZYHIMVKOHVIH-VILODJCFSA-N

Brusatol

Probe Information

Target Details

Probe Details

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Brusatol

Probe Information

Target Details

Probe Details

Supporting Organizations

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