Browse Probes

Probe Name Target name Target class Subclass Reviews Avg. Rating in Cells Avg. Rating in Vivo Published onsort descending
JQ1 BRD2, BRD3, BRD4, BRDT Epigenetics Bromodomain 3
4.0000
3.0000
 13 Jul 2015
CHIR-99021 GSK3A, GSK3B Protein kinase CMGC 3
3.6667
2.6667
 16 Jul 2015
Salvinorin A OPRK1 GPCR Opioid receptor 3
3.0000
3.0000
 16 Jul 2015
PFI-1 BRD2, BRD3, BRD4, BRDT Epigenetics Bromodomain 3
4.0000
2.6667
 16 Jul 2015
I-BET151 BRD2, BRD3, BRD4 Epigenetics Bromodomain 3
2.6667
2.6667
 16 Jul 2015
LLY-507 SMYD2 Epigenetics Protein methyltransferase 3
2.0000
0.0000
 02 Oct 2015
UNC1999 EZH1, EZH2 Epigenetics Protein methyltransferase 3
3.3333
1.3333
 02 Oct 2015
GSK343 EZH2 Epigenetics Protein methyltransferase 3
4.0000
0.0000
 02 Oct 2015
EPZ011989 EZH1, EZH2 Epigenetics Protein methyltransferase 3
3.6667
2.6667
 02 Oct 2015
OICR-9429 WDR5 Structural protein WD40-repeat proteins 3
4.0000
0.6667
 02 Oct 2015
UNC1215 L3MBTL3 Epigenetics Malignant brain tumor Reader 3
4.0000
1.0000
 02 Oct 2015
(R)-PFI-2 SETD7 Epigenetics Protein methyltransferase 3
4.0000
0.0000
 02 Oct 2015
SGC0946 DOT1L Epigenetics Protein methyltransferase 4
3.7500
0.0000
 02 Oct 2015
EPZ-5676 DOT1L Epigenetics Protein methyltransferase 3
3.6667
3.3333
 02 Oct 2015
SGC707 PRMT3 Epigenetics Protein methyltransferase 4
3.7500
2.0000
 02 Oct 2015
UNC0638 EHMT2, EHMT1 Epigenetics Protein methyltransferase 3
2.3333
1.0000
 02 Oct 2015
A-366 EHMT2, EHMT1 Epigenetics Protein methyltransferase 3
4.0000
1.6667
 02 Oct 2015
I-CBP112 CREBBP, EP300 Epigenetics Bromodomain 3
3.0000
2.0000
 03 Nov 2015
SGC-CBP30 CREBBP, EP300 Epigenetics Bromodomain 3
3.3333
0.0000
 03 Nov 2015
GSK-J4 KDM6A, KDM6B Epigenetics Lysine demethylase 3
3.3333
1.0000
 04 Nov 2015
EPZ020411 PRMT6 Epigenetics Protein methyltransferase 3
2.6667
2.6667
 05 Nov 2015
MS023 PRMT1, PRMT3, PRMT4, PRMT6, PRMT8 Epigenetics Protein methyltransferase 3
4.0000
0.0000
 05 Nov 2015
BAY-598 SMYD2 Epigenetics Protein methyltransferase 3
4.0000
4.0000
 09 Nov 2015
A-196 KMT5B, KMT5C Epigenetics Protein methyltransferase 3
4.0000
1.0000
 09 Nov 2015
GSK484 PADI4 Epigenetics Arginine deaminase 3
3.6667
1.3333
 09 Nov 2015
AGI-5198 IDH1 R132H Other Dehydrogenase 3
2.0000
1.6667
 10 Nov 2015
GSK864 IDH1 R132C/R132H/R132G Other Dehydrogenase 2
3.0000
2.5000
 10 Nov 2015
Trametinib MAP2K1, MAP2K2 Protein kinase STE 0 10 Dec 2015
BIX-02188 MAP2K5 Protein kinase STE 3
3.0000
1.3333
 10 Dec 2015
WH-4-023 LCK, SRC Protein kinase TK 5
1.8000
0.8000
 10 Dec 2015
GSK2334470 PDK1 Protein kinase AGC 3
4.0000
2.6667
 10 Dec 2015
SGX-523 MET Protein kinase TK 3
3.6667
3.6667
 10 Dec 2015
Imatinib BCR-ABL, PDGFR, KIT Protein kinase TK 3
1.0000
1.0000
 10 Dec 2015
Rapamycin MTOR Protein kinase Atypical 3
3.3333
3.0000
 10 Dec 2015
Tofacitinib JAK1, JAK2, JAK3 Protein kinase TK 3
3.6667
2.3333
 10 Dec 2015
PF-3758309 PAK1, PAK4, PAK5, PAK6 Protein kinase STE 4
2.5000
2.5000
 10 Dec 2015
Ruxolitinib JAK1, JAK2 Protein kinase TK 3
4.0000
4.0000
 10 Dec 2015
CFI-400945 PLK4 Protein kinase Other 3
1.6667
1.6667
 10 Dec 2015
PF3644022 MAPKAPK2 Protein kinase CAMK 3
3.3333
2.3333
 10 Dec 2015
HG-9-91-01 SIK1, SIK2, SIK3 Protein kinase CAMK 3
3.0000
1.6667
 10 Dec 2015
BYL-719 PIK3CA Lipid kinase Class I 3
4.0000
4.0000
 10 Dec 2015
CCT241533 CHEK2 Protein kinase CAMK 3
3.6667
0.6667
 10 Dec 2015
THZ1 CDK7 Protein kinase CMGC 3
3.3333
3.0000
 10 Dec 2015
AZD2014 MTOR Protein kinase Atypical 3
3.6667
4.0000
 10 Dec 2015
URMC-099 MLK1, MLK2, MLK3 Protein kinase TKL 3
1.3333
1.3333
 10 Dec 2015
BI-D1870 RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6 Protein kinase AGC 3
2.0000
0.3333
 10 Dec 2015
PRT062607 SYK Protein kinase TK 3
3.6667
3.6667
 10 Dec 2015
AMG900 AURKA, AURKB, AURKC Protein kinase cell cycle-regulated kinase 3
3.6667
3.6667
 10 Dec 2015
KU-60019 ATM Protein kinase Atypical 3
2.0000
1.6667
 10 Dec 2015
JNK-IN-8 MAPK8, MAPK9, MAPK10 Protein kinase CMGC 3
3.3333
0.6667
 10 Dec 2015
Selumetinib MAP2K1 Protein kinase STE 3
3.3333
3.0000
 10 Dec 2015
NVP-AEW541 IGF1R Protein kinase TK 3
3.3333
3.0000
 10 Dec 2015
WZ4003 NUAK1, NUAK2 Protein kinase CAMK 3
3.0000
0.6667
 10 Dec 2015
AC220 FLT3 Protein kinase TK 3
3.3333
2.6667
 10 Dec 2015
BI2536 PLK1, PLK2, PLK3 Protein kinase Other 3
2.0000
2.0000
 10 Dec 2015
STO609 CAMKK1, CAMKK2 Protein kinase Other 3
2.6667
0.0000
 10 Dec 2015
GNE7915 LRRK2 Protein kinase TKL 3
3.0000
3.0000
 10 Dec 2015
BGJ-398 FGFR1, FGFR2, FGFR3, FGFR4 Protein kinase TK 3
3.6667
3.3333
 10 Dec 2015
Pictilisib PIK3CA, PIK3CD Lipid kinase Class I 4
2.7500
2.5000
 10 Dec 2015
MPS1-IN-1 MPS1 Protein kinase Other 3
2.6667
0.6667
 10 Dec 2015
Afatinib EGFR, ERBB2 Protein kinase RTK 3
2.6667
2.6667
 10 Dec 2015
PF-477736 CHEK1 Protein kinase CAMK 3
3.6667
3.6667
 10 Dec 2015
AZD1152 AURKB Protein kinase cell cycle-regulated kinase 3
3.6667
3.6667
 10 Dec 2015
VE-821 ATR Protein kinase Atypical 3
2.6667
0.0000
 10 Dec 2015
OTSSP167 MELK Protein kinase CAMK 2
1.5000
1.0000
 10 Dec 2015
PF-4800567 CSNK1E Protein kinase CK1 3
2.0000
0.6667
 10 Dec 2015
CX-4945 CSNK2A1 Protein kinase CMGC 3
2.3333
2.0000
 10 Dec 2015
Bafetinib BCR-ABL, LYN Protein kinase TK 4
2.7500
2.5000
 10 Dec 2015
DDR1-IN-1 DDR1 Protein kinase TK 3
2.6667
0.6667
 10 Dec 2015
AZ191 DYRK1B Protein kinase CMGC 3
3.0000
0.0000
 10 Dec 2015
MK-5108 AURKA Protein kinase cell cycle-regulated kinase 3
4.0000
4.0000
 10 Dec 2015
AVL-292 BTK Protein kinase TK 3
2.6667
2.3333
 10 Dec 2015
XMD8-92 MAPK7 Protein kinase CMGC 3
2.6667
1.0000
 10 Dec 2015
CH5424802 ALK Protein kinase RTK 3
4.0000
4.0000
 10 Dec 2015
CP-724714 ERBB2 Protein kinase RTK 3
4.0000
4.0000
 10 Dec 2015
CP-673451 PDGFRβ Protein kinase TK 3
2.3333
1.6667
 10 Dec 2015
CGI1746 BTK Protein kinase TK 3
4.0000
4.0000
 10 Dec 2015
BMS-265246 CDK, CDK2 Protein kinase CMGC 3
2.0000
0.6667
 10 Dec 2015
GDC-0879 BRAF V600E Protein kinase TKL 3
3.6667
1.6667
 10 Dec 2015
SCH772984 MAPK1, MAPK3 Protein kinase CMGC 3
4.0000
3.3333
 10 Dec 2015
BMX-IN-1 BMX Protein kinase TK 3
3.0000
0.0000
 10 Dec 2015
KH-CB19 CLK1, CLK4, DYRK1A Protein kinase CMGC 3
3.0000
0.6667
 10 Dec 2015
VX-745 MAPK14 Protein kinase CMGC 3
4.0000
3.6667
 10 Dec 2015
PD0332991 CDK4, CDK6 Protein kinase CMGC 3
4.0000
3.0000
 10 Dec 2015
TX1-85-1 ERBB3 Protein kinase RTK 3
1.6667
0.0000
 10 Dec 2015
GNF-5 BCR-ABL Protein kinase TK 3
3.6667
3.3333
 10 Dec 2015
EPZ015666 PRMT5 Epigenetics Protein methyltransferase 3
4.0000
4.0000
 25 Jan 2016
GSK591 PRMT5 Epigenetics Protein methyltransferase 3
3.3333
1.3333
 25 Jan 2016
ABPA3 UBA1, UBA3 Other post-translational modification Ubiquitin-conjugating enzyme 3
2.0000
1.3333
 29 Jul 2016
AZ0108 PARP1, PARP2, PARP6 Other post-translational modification PARP 3
2.6667
2.0000
 29 Jul 2016
AZ6102 TNKS, TNKS2 Other post-translational modification PARP 3
3.0000
2.0000
 29 Jul 2016
BAZ2-ICR BAZ2A, BAZ2B Epigenetics Bromodomain 3
3.0000
1.3333
 29 Jul 2016
BI-9564 BRD9, BRD7 Epigenetics Bromodomain 3
3.0000
3.0000
 29 Jul 2016
BMS-911543 JAK2 Protein kinase TK 3
3.6667
3.6667
 29 Jul 2016
E7449 PARP1, PARP2, TNKS, TNKS2 Other post-translational modification PARP 3
3.0000
3.0000
 29 Jul 2016
GSK2801 BAZ2A, BAZ2B Epigenetics Bromodomain 3
2.3333
1.3333
 29 Jul 2016
I-BRD9 BRD9 Epigenetics Bromodomain 3
3.0000
0.0000
 29 Jul 2016
JQEZ5 EZH2 Epigenetics Protein methyltransferase 3
2.0000
2.3333
 29 Jul 2016
JW55 TNKS, TNKS2 Other post-translational modification PARP 3
1.0000
0.3333
 29 Jul 2016
Niraparib PARP1, PARP2 Other post-translational modification PARP 3
4.0000
3.6667
 29 Jul 2016
Olaparib PARP1, PARP2 Other post-translational modification PARP 3
3.0000
3.0000
 29 Jul 2016
Talazoparib PARP1, PARP2 Other post-translational modification PARP 3
3.3333
3.6667
 29 Jul 2016
Veliparib PARP1, PARP2 Other post-translational modification PARP 3
4.0000
2.6667
 29 Jul 2016
XAV939 TNKS, TNKS2, PARP1, PARP2 Other post-translational modification PARP 3
1.3333
0.0000
 29 Jul 2016
LP99 BRD7, BRD9 Epigenetics Bromodomain 3
2.0000
0.0000
 29 Jul 2016
CPI-360 EZH2 Epigenetics Protein methyltransferase 3
4.0000
2.3333
 08 Aug 2016
DS-437 PRMT5, PRMT7 Epigenetics Protein methyltransferase 3
2.0000
0.3333
 08 Aug 2016
UNC0642 EHMT2, EHMT1 Epigenetics Protein methyltransferase 3
4.0000
2.6667
 08 Aug 2016
EPZ-6438 EZH2 Epigenetics Protein methyltransferase 3
3.3333
2.3333
 08 Aug 2016
EI1 EZH2 Epigenetics Protein methyltransferase 3
3.6667
1.3333
 08 Aug 2016
CPI-169 EZH1, EZH2 Epigenetics Protein methyltransferase 3
4.0000
2.3333
 08 Aug 2016
BIX-01294 EHMT2 Epigenetics Protein methyltransferase 3
1.6667
1.0000
 08 Aug 2016
MIV-6R KMT2A Epigenetics Protein methyltransferase 3
2.3333
0.6667
 08 Aug 2016
EPZ004777 DOT1L Epigenetics Protein methyltransferase 3
4.0000
0.3333
 08 Aug 2016
CCT244747 CHEK1 Protein kinase CAMK 3
3.3333
3.0000
 09 Sep 2016
UNC3866 CBX7, CBX4 Epigenetics Methyl-lysine reader 3
2.6667
0.0000
 09 Sep 2016
Cortistatin A CDK8, CDK19 Protein kinase CMGC 3
1.6667
1.0000
 09 Sep 2016
JAK3i JAK3 Protein kinase TK 3
2.3333
2.3333
 09 Sep 2016
ML323 USP1, WDR48 Other post-translational modification Deubiquitinase 3
3.3333
0.0000
 14 Oct 2016
RSL3 GPX4 Lipid metabolism Glutathione Peroxidase 3
2.3333
2.0000
 14 Oct 2016
eCF309 MTOR Protein kinase Atypical 3
3.0000
0.0000
 17 Oct 2016
PDD00017273 PARG DNA replication & repair enzyme Glycohydrolase 3
3.3333
0.3333
 18 Oct 2016
MT1 BRD2, BRD3, BRD4, BRDT Epigenetics Bromodomain 3
4.0000
4.0000
 04 Nov 2016
VH298 VHL Other post-translational modification E3 ubiquitin ligase 3
3.6667
0.0000
 15 Nov 2016
MZ1 BRD4 Epigenetics Bromodomain 4
3.5000
0.0000
 18 Nov 2016
G-5555 PAK1, PAK2, PAK3 Protein kinase STE 3
3.6667
2.6667
 29 Nov 2016
NVS-PAK1-1 PAK1 Protein kinase STE 3
3.6667
1.3333
 29 Nov 2016
AX15836 MAPK7 Protein kinase CMGC 3
4.0000
0.6667
 05 Dec 2016
AMG-18 ERN1 Protein kinase Other 3
3.3333
2.0000
 08 Dec 2016
BiBET BRD4, BRD3, BRD2, BRDT Epigenetics Bromodomain 3
3.3333
0.6667
 12 Dec 2016
CCT251545 CDK8, CDK19 Protein kinase CMGC 3
4.0000
3.3333
 13 Jan 2017
CCT251236 PIR Other Cupin 3
3.6667
3.0000
 17 Jan 2017
NI-42 BRPF1, BRD1, BRPF3 Epigenetics Bromodomain 3
1.6667
1.6667
 30 Jan 2017
A-395 EED Epigenetics Polycomb family 3
3.6667
2.0000
 31 Jan 2017
Englerin A TRPC4, TRPC5 Ion channel Transient receptor potential channels 3
2.0000
0.3333
 31 Jan 2017
Filgotinib JAK1 Protein kinase TK 3
3.3333
3.6667
 10 Feb 2017
GSK481 RIPK1 Protein kinase TKL 3
4.0000
0.0000
 16 Feb 2017
eCF506 SRC Protein kinase TK 4
3.0000
2.2500
 23 Feb 2017
PFI-3 SMARCA2, SMARCA4, PBRM1 Epigenetics Bromodomain 2
4.0000
1.0000
 07 Mar 2017
Venetoclax BCL2 Other Protein Phosphatase 3
4.0000
4.0000
 07 Mar 2017
GSK583 RIPK2 Protein kinase TKL 3
3.6667
3.3333
 09 Mar 2017
GSK4027 PCAF, GCN5 Epigenetics Bromodomain 5
3.8000
1.4000
 13 Mar 2017
L-Moses PCAF, GCN5 Epigenetics Bromodomain 6
2.5000
0.3333
 13 Mar 2017
PF-CBP1 CREBBP, EP300 Epigenetics Bromodomain 3
3.6667
0.0000
 13 Mar 2017
2-MT 63 TEK Protein kinase TK 3
2.6667
2.6667
 13 Mar 2017
BLU9931 FGFR4 Protein kinase TK 3
3.6667
2.6667
 14 Mar 2017
AGI-6780 IDH2 R140Q Other Dehydrogenase 3
2.0000
0.3333
 14 Mar 2017
Skepinone-L MAPK14 Protein kinase CMGC 3
3.6667
3.0000
 15 Mar 2017
EED226 EED Epigenetics Polycomb family 4
3.7500
2.7500
 30 Mar 2017
A-1155463 BCL2L1 Other Apoptosis regulator 3
3.0000
2.6667
 04 Apr 2017
A-1210477 MCL1 Other BCL2 family 3
2.6667
1.0000
 04 Apr 2017
GSK-5959 BRPF1 Epigenetics Bromodomain 3
2.3333
0.0000
 04 Apr 2017
UNC2025 MERTK, FLT3 Protein kinase TK 3
3.0000
3.0000
 06 Apr 2017
RGFP966 HDAC3 Epigenetics HDAC 3
3.0000
3.0000
 10 Apr 2017
ACY-738 HDAC6 Epigenetics HDAC 3
3.0000
2.6667
 10 Apr 2017
Tubacin HDAC6 Epigenetics HDAC 3
3.3333
2.0000
 10 Apr 2017
Romidepsin HDAC1, HDAC2, HDAC3, HDAC8 Epigenetics HDAC 3
3.6667
3.0000
 11 Apr 2017
FM-381 JAK3 Protein kinase TK 3
4.0000
0.0000
 24 Apr 2017
S63845 MCL1 Other BCL2 family 4
4.0000
3.0000
 24 Apr 2017
CPI-0610 BRD2, BRD3, BRD4, BRDT Epigenetics Bromodomain 3
4.0000
4.0000
 24 Apr 2017
CPI-637 CREBBP, EP300 Epigenetics Bromodomain 3
2.3333
0.0000
 25 Apr 2017
GPR40ant39 FFAR1 GPCR Free fatty acid receptors 3
2.3333
2.0000
 10 May 2017
BAY-299 BRD1, TAF1, TAF1L Epigenetics Bromodomain 3
2.3333
1.0000
 11 May 2017
GNE-2861 PAK4, PAK5, PAK6 Protein kinase STE 3
2.6667
0.0000
 30 May 2017
KI-696 KEAP1 Other post-translational modification Protein ubiquitination 3
3.3333
2.3333
 01 Jun 2017
MI-888 MDM2 Other post-translational modification E3 ubiquitin ligase 3
3.0000
3.0000
 06 Jun 2017
RO5353 MDM2 Other post-translational modification E3 ubiquitin ligase 2
4.0000
4.0000
 06 Jun 2017
RO2468 MDM2 Other post-translational modification E3 ubiquitin ligase 2
3.0000
3.5000
 06 Jun 2017
AMG232 MDM2 Other post-translational modification E3 ubiquitin ligase 3
4.0000
3.6667
 06 Jun 2017
MI-77301 MDM2 Other post-translational modification E3 ubiquitin ligase 3
4.0000
4.0000
 06 Jun 2017
RG7112 MDM2 Other post-translational modification E3 ubiquitin ligase 2
3.0000
3.5000
 06 Jun 2017
AM-6761 MDM2 Other post-translational modification E3 ubiquitin ligase 3
4.0000
4.0000
 06 Jun 2017
Pevonedistat UBA3 Other post-translational modification Ubiquitin-conjugating enzyme 3
3.0000
2.0000
 06 Jun 2017
RG7388 MDM2 Other post-translational modification E3 ubiquitin ligase 3
3.6667
3.6667
 06 Jun 2017
Taxol Beta-Tubulin Structural protein Cytoskeleton 1
4.0000
4.0000
 10 Jun 2017
NMS-P118 PARP1 Other post-translational modification PARP 2
3.0000
3.5000
 14 Jun 2017
KZR-504 PSMB9 Protein metabolism Proteasome subunit 3
3.6667
3.3333
 21 Jun 2017
WEHI-539 BCL2L1 Other Apoptosis regulator 2
3.5000
0.5000
 22 Jun 2017
Cotransin SEC61 complex Integral membrane protein General secrectory pathway 3
2.3333
0.0000
 23 Jun 2017
TTT20171 SDHC Other TCA cycle 2
1.0000
1.0000
 27 Jun 2017
Linsitinib IGF1R, INSR, INSRR Protein kinase TK 3
4.0000
4.0000
 27 Jun 2017
Bistramide A Actin Structural protein Cytoskeleton 3
3.0000
0.3333
 27 Jun 2017
CPI-1205 EZH2 Epigenetics Protein methyltransferase 3
3.0000
2.6667
 06 Jul 2017
Eleutherobin Tubulin Structural protein Cytoskeleton 3
3.0000
0.0000
 17 Jul 2017
T0901317 NR1H3, NR1H2 Other NR1 Subfamily 3
3.6667
4.0000
 18 Jul 2017
GW3965 NR1H3, NR1H2 Other NR1 Subfamily 3
3.0000
3.6667
 18 Jul 2017
PF-4181366 PDE9A Nucleic acid metabolism Phosphodiesterase 0 20 Jul 2017
Tubastatin A HDAC6, HDAC10 Epigenetics HDAC 2
3.0000
3.0000
 20 Jul 2017
TUG-891 FFAR4 GPCR Free fatty acid receptor 0 21 Jul 2017
NI-57 BRPF1, BRD1, BRPF3 Epigenetics Bromodomain 3
3.0000
2.3333
 25 Jul 2017
GSK2033 NR1H3, NR1H2 Other NR1 Subfamily 0 27 Jul 2017
ICI-199441 OPRK1 GPCR Opioid receptors 3
3.0000
2.6667
 09 Aug 2017
Glyburide ABCC8, KCNJ11 Ion channel Potassium channel 2
3.0000
3.5000
 09 Aug 2017
Repaglinide ABCC8, KCNJ11 Ion channel Potassium channel 2
2.5000
3.0000
 09 Aug 2017
T-26c MMP13 Protein metabolism Metallopeptidase 2
3.0000
2.0000
 09 Aug 2017
(R)-9s ADRA1D GPCR Alpha-Adrenergic Receptor 3
3.6667
3.6667
 31 Jan 2020
CM11 VHL Other post-translational modification E3 ubiquitin ligase 3
4.0000
0.0000
 05 Mar 2020
AT1 BRD4 Epigenetics Bromodomain 3
4.0000
0.6667
 05 Mar 2020
ABBV-744 BET BD2 Epigenetics Bromodomain 3
3.3333
3.3333
 29 Apr 2020
Luminespib HSP90 Other post-translational modification Chaperone 3
4.0000
3.6667
 11 May 2020
BAY-985 TBK1, IKBKE Protein kinase Ser/Thr Protein Kinase 3
3.0000
2.3333
 16 May 2020
BAY-885 MAPK7 Protein kinase CMGC 3
2.6667
0.0000
 17 May 2020
FS-694 MAPK14 Protein kinase CMGC 1
4.0000
0.0000
 17 May 2020
MLi-2 LRRK2 Protein kinase TKL 2
3.0000
2.5000
 17 May 2020
A-485 CREBBP, EP300 Epigenetics Bromodomain 3
3.3333
3.0000
 20 May 2020
ABT-100 FNTB Other post-translational modification Transferase 2
2.5000
3.5000
 21 May 2020
BI-1935 EPHX2 Other Epoxide Hydrolase 2 1
4.0000
4.0000
 24 May 2020
BAY-707 NUDT1 Epigenetics Nudix Hydrolase 2
3.5000
2.0000
 24 May 2020
BI-2545 ENPP2 Other Phosphodiesterase 3
3.6667
3.6667
 24 May 2020
BTZO-1 MIF Other post-translational modification Tautomerase 2
4.0000
1.0000
 25 May 2020
THPP-1 PDE10A Epigenetics Phosphodiesterase 2
3.5000
4.0000
 26 May 2020
AC-4-130 STAT5B Transcription factor Signal transducer and transcription activator 3
2.3333
2.0000
 27 May 2020
UCSF4226 MTNR1B GPCR Melatonin Receptor 3
3.6667
3.3333
 29 May 2020
Ogerin GPR68 GPCR Proton Sensing GPCR 1
3.0000
3.0000
 29 May 2020
UCSF7447 MTNR1A GPCR Melatonin Receptor 2
3.5000
3.0000
 29 May 2020
(R)-Zinc-3573 MRGPRX2 GPCR Mast cell-specific receptor 2
1.5000
1.5000
 29 May 2020
TP-024 GPR52 GPCR A orphan G protein-coupled receptor 0 29 May 2020
MRK-740 PRDM9 Epigenetics Histone methyltransferase 1
4.0000
0.0000
 29 May 2020
SR-318 MAPK14 Protein kinase CMGC 1
4.0000
2.0000
 02 Jun 2020
SD-36 STAT3 Transcription factor Signal transducer and transcription activator 2
4.0000
4.0000
 04 Jun 2020
BAY-549 ROCK1, ROCK2 Protein kinase AGC 3
3.0000
3.0000
 06 Jun 2020
MRTX849 KRAS G12C Other GTPase 3
4.0000
4.0000
 10 Jun 2020
AMG-510 KRAS G12C Other GTPase 3
4.0000
4.0000
 10 Jun 2020
ARS-1620 KRAS G12C Other GTPase 0 11 Jun 2020
TH5427 NUDT5 Epigenetics Nudix Hydrolase 2
4.0000
0.0000
 12 Jun 2020
BAY-826 TIE1, TEK, DDR1, DDR2 Protein kinase TK 1
3.0000
3.0000
 15 Jun 2020
DO264 ABHD12 Lipid metabolism Serine Esterase 2
3.5000
3.5000
 16 Jun 2020
ULK-101 ULK1, ULK2 Protein kinase Autophagy Activating Kinases 2
3.5000
0.0000
 17 Jun 2020
EML631 SPIN1 Transcription factor Chromatin regulator 0 17 Jun 2020
MLT-748 MALT1 Other Peptidase C14B 1
4.0000
0.0000
 17 Jun 2020
25CN-NBOH HTR2A, HTR2C, GPCR Serotonin Receptor 3
4.0000
3.6667
 17 Jun 2020
TP-004 METAP2 Other Methionine Aminopeptidase 2
2.5000
2.5000
 23 Jun 2020
CPI-1612 CREBBP, EP300 Epigenetics Bromodomain 3
3.3333
3.0000
 23 Jun 2020
RUSKI-201 HHAT Other post-translational modification O-acyltransferase 3
2.6667
0.0000
 07 Jul 2020
WM-1119 KAT6A Other Lysine Acetyltransferase 2
3.0000
3.0000
 09 Jul 2020
M-808 MEN1 Epigenetics Scaffold Protein 3
2.3333
2.0000
 09 Jul 2020
AB680 CD73 Other Membrane Protein 3
3.6667
3.6667
 09 Jul 2020
AMG 176 MCL1 Other BCL2 family 2
3.0000
2.5000
 10 Jul 2020
LNP-023 CFB Other Serine Protease 1
4.0000
4.0000
 10 Jul 2020
MCC950 NLRP3 Other NACHT, LRR and PYD domains-containing Protein 1
3.0000
3.0000
 10 Jul 2020
SR9238 NR1H3, NR1H2 Other NR1 Subfamily 0 16 Jul 2020
LXR-623 NR1H3, NR1H2 Other NR1 Subfamily 2
2.5000
2.0000
 16 Jul 2020
SR9243 NR1H3, NR1H2 Other NR1 Subfamily 0 16 Jul 2020
CMLD-2 ELAVL1 Other RNA Binding Protein 2
2.0000
0.0000
 16 Jul 2020
BAY-1816032 BUB1 Protein kinase Ser/Thr Protein Kinase 2
4.0000
4.0000
 20 Jul 2020
PT2399 HIF-2α Transcription factor Hypoxia-Inducible Factor 1
4.0000
4.0000
 28 Jul 2020
BAY-3827 PRKAA1, RPS6KA1 Protein kinase CAMK 2
3.5000
0.0000
 03 Aug 2020
BAY1125976 AKT1, AKT2 Protein kinase AGC 3
3.6667
3.6667
 10 Aug 2020
PT2385 HIF-2α Transcription factor Hypoxia-Inducible Factor 3
3.6667
3.6667
 23 Sep 2020
TP-020 MGAT2 Other post-translational modification N-acetylglucosaminyltransferase 1
2.0000
3.0000
 24 Sep 2020
XMD8-87 ACK1 Protein kinase TK 3
2.0000
0.0000
 13 Oct 2020
THZ531 CDK12, CDK13 Protein kinase CMGC 3
3.6667
0.0000
 14 Oct 2020
XMD-12 AURKA, AURKB, AURKC Protein kinase cell cycle-regulated kinase 3
3.6667
2.0000
 14 Oct 2020
PF-06869206 SLC34A1 Other SLC Family 2
3.0000
3.0000
 20 Oct 2020
GSK2194069 FASN Lipid metabolism Synthase 2
3.5000
2.5000
 21 Oct 2020
GSK2982772 RIPK1 Protein kinase TKL 3
4.0000
3.3333
 21 Oct 2020
MBM-55 NEK2 Protein kinase Ser/Thr Protein Kinase 2
3.0000
2.5000
 22 Oct 2020
QC6352 KDM4C Epigenetics Protein Demethylase 3
4.0000
4.0000
 22 Oct 2020
LSN 3213128 ATIC Other formyltransferase and cyclohydrolase 1
4.0000
4.0000
 22 Oct 2020
NCT-505 ALDH1A1 Other aldehyde dehydrogenase 2
2.0000
1.0000
 22 Oct 2020
SB-612111 OPRL1 GPCR Opioid receptor 3
3.6667
3.6667
 23 Oct 2020
GSK2973980A DGAT1 Other Diacylglycerol O-acyltransferase 2
3.0000
3.0000
 23 Oct 2020
AZD3988 DGAT1 Other Diacylglycerol O-acyltransferase 3
4.0000
4.0000
 23 Oct 2020
AZD-6482 PIK3CB Lipid kinase Class I 3
3.0000
3.3333
 26 Oct 2020
Capmatinib MET Protein kinase TK 2
4.0000
4.0000
 26 Oct 2020
Adavosertib WEE1 Protein kinase Ser/Thr Protein Kinase 3
3.0000
3.0000
 26 Oct 2020
NIK SMI1 MAP3K14 Protein kinase STE 2
3.5000
3.5000
 27 Oct 2020
Relacatib CTSK, CTSL, CTSV Protein metabolism Protease 3
3.3333
3.3333
 27 Oct 2020
RU.521 GAS Other cyclic GMP-AMP synthase 2
2.5000
0.0000
 05 Nov 2020
BSJ-03-123 CDK6 Protein kinase CMGC 3
4.0000
0.0000
 12 Nov 2020
VZ185 BRD7, BRD9 Epigenetics Bromodomain 3
3.6667
0.0000
 12 Nov 2020
TBK1 PROTAC 3i TBK1 Protein kinase Ser/Thr Protein Kinase 3
3.0000
0.0000
 12 Nov 2020
THAL-SNS-032 CDK9, CDK10 Protein kinase CMGC 3
3.6667
0.0000
 12 Nov 2020
TL13-112 ALK Protein kinase RTK 0 12 Nov 2020
dTRIM24 TRIM24 Epigenetics Tripartite Motif Family 2
3.0000
0.0000
 13 Nov 2020
TH1760 NUDT15 Epigenetics Nudix Hydrolase 3
3.6667
0.6667
 16 Nov 2020
GNF-5837 TRKA, TRKB, TRKC Protein kinase TK 3
3.6667
3.0000
 17 Nov 2020
TAK-243 UBA1 Other post-translational modification Ubiquitin-conjugating enzyme 2
3.5000
3.5000
 17 Nov 2020
GDC-0834 BTK Protein kinase TK 3
3.0000
2.0000
 17 Nov 2020
Asciminib BCR-ABL Protein kinase TK 3
4.0000
4.0000
 23 Nov 2020
dBET6 BRD4 Epigenetics Bromodomain 3
4.0000
3.6667
 23 Nov 2020
MG-277 GSPT1 Other Translation Termination Factor 1
3.0000
0.0000
 24 Nov 2020
MD-224 MDM2 Other post-translational modification E3 ubiquitin ligase 2
3.5000
3.5000
 24 Nov 2020
MZP-54 BRD2, BRD3, BRD4 Epigenetics Bromodomain 2
2.5000
0.0000
 25 Nov 2020
GNE-049 CREBBP, EP300 Epigenetics Bromodomain 1
4.0000
3.0000
 25 Nov 2020
GNE-781 CREBBP, EP300 Epigenetics Bromodomain 2
4.0000
4.0000
 25 Nov 2020
WZ4002 EGFR Protein kinase RTK 3
3.0000
3.0000
 25 Nov 2020
A-770041 LCK Protein kinase TK 3
3.6667
3.3333
 25 Nov 2020
MK-8033 MET, MST1R Protein kinase TK 2
3.5000
3.5000
 26 Nov 2020
AMG 337 MET Protein kinase TK 3
3.6667
4.0000
 26 Nov 2020
U18666A NPC1 Other Intracellular Cholesterol Transporter 3
2.6667
2.0000
 26 Nov 2020
AC710 PDGFRα, PDGFRβ, KIT, FLT3, CSF1R Protein kinase TK 2
2.0000
2.0000
 27 Nov 2020
G749 FLT3 Protein kinase TK 3
2.0000
1.3333
 27 Nov 2020
AZ-960 JAK2 Protein kinase TK 1
4.0000
0.0000
 27 Nov 2020
ARCC-4 AR Transcription factor Nuclear Hormone Receptor 1
4.0000
0.0000
 30 Nov 2020
ARD-266 AR Transcription factor Nuclear Hormone Receptor 1
3.0000
0.0000
 30 Nov 2020
PF-3845 FAAH Lipid metabolism Serine Hydrolase 1
4.0000
2.0000
 30 Nov 2020
PF-04457845 FAAH Lipid metabolism Serine Hydrolase 1
2.0000
4.0000
 30 Nov 2020
dBRD9 BRD9 Epigenetics Bromodomain 3
3.6667
0.0000
 30 Nov 2020
BIIB021 HSP90AA1, HSP90AB1 Other post-translational modification Chaperone 0 01 Dec 2020
CP-10 CDK6 Protein kinase CMGC 2
3.0000
0.0000
 01 Dec 2020
AZD9496 ESR1 Other NR3 Subfamily 3
4.0000
3.3333
 02 Dec 2020
Onalespib HSP90 Other post-translational modification Chaperone 0 02 Dec 2020
DT2216 BCL2L1 Other Apoptosis Regulator 3
3.6667
3.6667
 03 Dec 2020
GNE-9822 ITK Protein kinase TK 0 03 Dec 2020
AZD4547 FGFR1, FGFR2, FGFR3 Protein kinase TK 0 03 Dec 2020
MS436 BRD4, BRD3 Epigenetics Bromodomain 0 03 Dec 2020
VinSpinIn SPIN1 Transcription factor Chromatin Regulator 1
3.0000
0.0000
 17 Dec 2020
PI-3065 PIK3CD Lipid kinase Class I 2
3.0000
2.5000
 17 Dec 2020
CRBN-6-5-5-VHL CRBN Other post-translational modification E3 Ligase 3
3.3333
0.6667
 17 Dec 2020
SU6656 SRC, YES1, LYN, FYN Protein kinase TK 0 06 Jan 2021
XL019 JAK2 Protein kinase TK 3
2.3333
2.6667
 07 Jan 2021
Rociletinib EGFR Protein kinase RTK 0 07 Jan 2021
GPR120-IN-1 FFAR4 GPCR Free fatty acid receptor 3
2.6667
2.0000
 08 Jan 2021
GLPG0974 FFAR2 GPCR Free fatty acid receptor 1
4.0000
4.0000
 12 Jan 2021
Fasiglifam FFAR1 GPCR Free fatty acid receptor 2
3.5000
3.5000
 12 Jan 2021
TUG-469 FFAR1 GPCR Free fatty acid receptor 2
3.5000
3.5000
 12 Jan 2021
SJF1528 EGFR, ERBB2 Protein kinase RTK 2
3.5000
0.0000
 15 Jan 2021
Canertinib EGFR, ERBB2 Protein kinase RTK 0 18 Jan 2021
Lapatinib EGFR, ERBB2 Protein kinase RTK 0 19 Jan 2021
BI-3812 BCL6 Transcription factor Transcriptional Repressor 3
3.0000
0.0000
 20 Jan 2021
BI-3802 BCL6 Transcription factor Transcriptional Repressor 3
4.0000
3.0000
 20 Jan 2021
AM-4668 FFAR1 GPCR Free fatty acid receptor 0 21 Jan 2021
AM-1638 FFAR1 GPCR Free fatty acid receptor 2
2.5000
1.5000
 21 Jan 2021
AMG-837 FFAR1 GPCR Free fatty acid receptor 3
3.3333
3.3333
 21 Jan 2021
GW1100 FFAR1 GPCR Free fatty acid receptor 0 22 Jan 2021
DS-1971a SCN9A Ion channel Sodium Voltage-Gated Channel 3
3.6667
3.0000
 29 Jan 2021
SGC-CK2-1 CSNK2A1, CSNK2A2 Protein kinase CMGC 2
3.0000
0.0000
 30 Jan 2021
SGC-CLK-1 CLK1, CLK2, CLK4 Protein kinase CMGC 2
3.0000
1.0000
 30 Jan 2021
Nidufexor NR1H4 Transcription factor Nuclear Receptor 0 30 Jan 2021
Roblitinib FGFR4 Protein kinase TK 0 01 Feb 2021
A-1331852 BCL2L1 Other Apoptosis Regulator 2
2.0000
2.0000
 01 Feb 2021
DDD85646 NMT1, NMT2 Other post-translational modification Acyltransferase 0 02 Feb 2021
BIX-02565 RPS6KA3 Protein kinase AGC 2
3.0000
1.0000
 02 Feb 2021
CFI-402257 TTK Protein kinase Other 1
4.0000
4.0000
 02 Feb 2021
GNE-3511 MAP3K12 Protein kinase TKL 3
3.0000
3.0000
 03 Feb 2021
Tacrolimus FKBP1A Other Immunophilin Protein Family 0 04 Feb 2021
GW788388 TGFBR1 Protein kinase TKL 2
2.5000
1.5000
 05 Feb 2021
Empesertib TTK Protein kinase Other 0 05 Feb 2021
BAY1217389 TTK Protein kinase Other 2
3.0000
3.0000
 05 Feb 2021
GSK256066 PDE4B Nucleic acid metabolism Phosphodiesterase 0 15 Feb 2021
Ceritinib ALK Protein kinase RTK 0 16 Feb 2021
Baricitinib JAK1, JAK2 Protein kinase TK 0 16 Feb 2021
Brigatinib ALK Protein kinase RTK 0 16 Feb 2021
Brivanib KDR Protein kinase TK 0 16 Feb 2021
Cabozantinib KDR Protein kinase TK 0 17 Feb 2021
Entospletinib SYK Protein kinase TK 3
3.6667
3.3333
 17 Feb 2021
Gandotinib JAK2 Protein kinase TK 3
3.0000
3.0000
 17 Feb 2021
SS-208 HDAC6 Epigenetics HDAC 2
3.5000
2.5000
 18 Feb 2021
AZD1332 NTRK1, NTRK2 Protein kinase TK 2
4.0000
4.0000
 22 Feb 2021
PIM-447 PIM1, PIM2, PIM3 Protein kinase CAMK 2
3.5000
3.5000
 24 Feb 2021
SGC-SMARCA-BRDVIII SMARCA2, SMARCA4, PBRM1 Epigenetics Bromodomain 2
4.0000
0.0000
 26 Feb 2021
BAY-6672 PTGFR GPCR Prostaglandin F Receptor 1
4.0000
4.0000
 01 Mar 2021
PF470 GRM5 GPCR Metabatropic Glutamate Receptor 0 05 Mar 2021
HTL14242 GRM5 GPCR Metabatropic Glutamate Receptor 1
4.0000
4.0000
 05 Mar 2021
ACBI1 SMARCA2, SMARCA4, PBRM1 Epigenetics Bromodomain 0 09 Mar 2021
BIIE0246 NPY2R GPCR Neuropeptide Y receptor Y2 1
4.0000
4.0000
 12 Mar 2021
CC-90009 GSPT1 Other Translation Termination Factor 0 15 Mar 2021
LYS006 LTA4H Other Hydrolase 0 16 Mar 2021
TAK-981 SAE1, UBA2 Other post-translational modification SUMOylation Enzyme 2
4.0000
4.0000
 16 Mar 2021
PFI-6 MLLT1, MLLT3 Epigenetics YEATS 0 16 Mar 2021
NVS-MLLT-1 MLLT1, MLLT3 Epigenetics YEATS 2
3.5000
0.0000
 16 Mar 2021
SGC-iMLLT MLLT1, MLLT3 Epigenetics YEATS 1
4.0000
0.0000
 16 Mar 2021
AM-6226 FFAR1 GPCR Free fatty acid receptor 0 26 Mar 2021
GSK8814 ATAD2, ATAD2B Epigenetics ATPase 0 28 Mar 2021
BAY-850 ATAD2 Epigenetics ATPase 3
3.0000
0.0000
 28 Mar 2021
1G244 DPP8, DPP9 Other post-translational modification Prolyl Peptidase 0 29 Mar 2021
GT949 SLC1A2 Other SLC Family 0 29 Mar 2021
BI-9627 SLC9A1 Other SLC Family 0 12 Apr 2021
PZ2891 PANK1, PANK2, PANK3 Protein kinase Pantothenate kinase 0 19 Apr 2021
BAY-876 SLC2A1 Other SLC Family 0 19 Apr 2021
Golvatinib MET, KDR Protein kinase TK 0 28 Apr 2021
STM2457 METTL3 Epigenetics Methyltransferase 3
3.6667
3.3333
 06 May 2021
NVP-2 CDK9 Protein kinase CMGC 1
4.0000
0.0000
 11 May 2021
IMP-1088 NMT1, NMT2 Other post-translational modification Acyltransferase 3
3.0000
0.6667
 18 May 2021
AG-270 MAT2A Other post-translational modification Methionine Adenosyltransferase 3
3.6667
3.6667
 20 May 2021
Vimirogant RORC Transcription factor NR1 nuclear hormone receptors 2
3.0000
3.0000
 20 May 2021
AS-99 ASH1L Epigenetics HMT 3
4.0000
3.3333
 25 May 2021
VT104 TEAD1, TEAD2, TEAD3, TEAD4 Transcription factor TEA Domain 2
4.0000
4.0000
 26 May 2021
VT103 TEAD1 Transcription factor TEA domain 2
3.0000
3.0000
 26 May 2021
CB-5083 VCP ATPase AAA+ 3
3.6667
3.6667
 26 May 2021
SR-0813 MLLT1, MLLT3 Epigenetics YEATS 0 10 Jun 2021
NMS-873 VCP ATPase AAA+ 2
2.0000
0.0000
 10 Jun 2021
GI254023X ADAM10 Other ADAM family 0 22 Jun 2021
IMP-1710 UCHL1 Other Peptidase C12 family 3
3.3333
0.0000
 22 Jun 2021
Tomivosertib MKNK1, MKNK2 Protein kinase CAMK 0 26 Jun 2021
AZD9833 ESR1 Other Hormone Receptor 0 11 Aug 2021
JQKD82 KDM5A Epigenetics Lysine demethylase 0 24 Aug 2021
SosBo4.27 ent2 SIRT1 Other Sirtuin family 0 13 Sep 2021
MK-8262 CETP Lipid metabolism Lipid transfer protein 0 24 Sep 2021
AS1517499 STAT6 Transcription factor Signal transducer and transcription activator 0 24 Sep 2021
Ozanimod S1PR1, S1PR5 GPCR Sphingosine-1-phosphate receptor 0 24 Sep 2021