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1H NMR (300 MHz, CDCl3) δ ppm 8.45 (s, 1H), 7.90 (s, 1H), 7,35 (m, 2H), 6.30 (br s, 1H), 5.40 (s, 1H), 5.15 (m, 1H), 4.80 (m, 1H), 1.60 (m, 3H), 1.35 (m, 6H).
In vitro selectivity profiling across a broad panel of 177 kinases (Millipore's Kinase Profiler) showed that 500 nM AZ-23 significantly inhibited (>75% inhibition) only a small subset of these enzymes: 24 nM (FGFR1), 52 nM (Flt3), 55 nM (Ret), 84 nM (MuSk), 99 nM (Lck)
Cell selectivity: 41 nM (FGFR1), 4077 nM (IGF1R), >1000 nM (Aurora), >3000 (CSF1R) >5000 nM (InsR, Akt, p70S6k, GSK3b)