AS1517499

Protein target name:

STAT6

Mechanism of action:

Inhibitor

Recommended Concentration for use in cells:

100 nM

Probe Availability

MedChemExpress

Selleck Chemicals

Probe Information

Target and Probe Information

Target Details

Target class:

Transcription factor

Subclass:

Signal transducer and transcription activator

HUGO ID:

HGNC:11368

Entrez gene ID:

6778

UNIPROT ID:

P42226

Target alias:

STAT6B; STAT6C; D12S1644; IL-4-STAT

Probe Details

Chemical Probes Portal ID:

CPP2467

Probe alias:

cpd 2t

PubChem CID:

10340781

ChEMBL ID:

CHEMBL228192

SMILES string:

C1=CC=C(C=C1)CNC2=NC(=NC=C2C(=O)N)NCCC3=CC(=C(C=C3)O)Cl

InChi Key:

OZRMEKAUZBKTTC-UHFFFAOYSA-N

Physico-chemical properties

NMR:

1H NMR (DMSO-d6, 80 °C) δ 2.68 (2H, t, J = 7.2 Hz), 3.40–3.42 (2H, m), 4.63 (2H, d, J = 6.0 Hz), 6.83–6.91 (3H, m), 7.10 (2H, br), 7.22–7.24 (1H, m), 7.28–7.31 (5H, m), 8.39 (1H, s), 9.33 (1H, br s), 9.57 (1H, s)

Validation in Cells and Model Organisms

In cell validation

On target activity in cells

Potency in cells:

IC50

21 nM, 2.3 nM

Potency assay (cells):

Reporter Assay, IL-4-induced Th2 differentiation inhibition

In vivo validation

Organism:

Mouse

Dose:

10 mg/Kg

Route of delivery:

Oral

Primary Reference

Reference (doi):

10.1016/j.bmc.2006.10.015

Reference (PMID):

17071093

AS1517499

Probe Availability

Probe Information

Target Details

STAT6B; STAT6C; D12S1644; IL-4-STAT

Probe Details

Physico-chemical properties

In cell validation

In vivo validation

Primary Reference

Supporting Organizations

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AS1517499

Probe Availability

Probe Information

Target Details

STAT6B; STAT6C; D12S1644; IL-4-STAT

Probe Details

Physico-chemical properties

In cell validation

In vivo validation

Primary Reference

Supporting Organizations

Interested in supporting the portal?