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up to 1 uM
1H NMR (500MHz) (DMSO-d6) d 12.25 (1H, s); 7.93 (2H, d, J =10 Hz); 7.84 (3H, m); 7.71 (1H, d, J = 10 Hz); 7.55 (2H, m); 7.29 (2H, d, J = 10 Hz); 7.00 (2H, d, J = 10 Hz); 5.19 (2H, m); 3.95 (1H, m); 2.61 (2H, m); 1.78 (3H, s).
Inactive on the closely related GPCRs GPR41 and GPR43. No significant activity in cell-based assays against PPARα, δ, and γ. An external panel of 64 receptors also revealed no significant activity with the exception of weak inhibition (IC50 = 3 uM) on the a2-adrenergic receptor.