AMG-458

Compound status: 
Historic compound: While this compound has been used to interrogate specific protein targets, it is not a chemical probe and should not be used in assays that depend on a potent and selective modulator of the protein.
Note about activity: 

Intended target=cMET; AMG-458 is more potent against RON and inhibits multiple kinases within 10-fold of its IC50 for MET (https://www.ebi.ac.uk/chembl/bioactivity/results/1/cmpd_chemblid/asc/tab...).

Probe Information