AT-101

Compound status:

Historic compound: While this compound has been used to interrogate specific protein targets, it is not a chemical probe and should not be used in assays that depend on a potent and selective modulator of the protein.

Note about activity:

Intended target: BCL2; AT-101 induces proaptotic NOXA; Soderquist & Eastman. BCL2 inhibitors as anticancer drugs: a plethora of misleading BH3 mimetics. Mol Cancer Ther. 15, 2011-7 (2016).

Probe Information

Target and Probe Information

Target Details

Probe Details

Probe alias:

Gossypol acetic acid; Gossypol-Acetic acid; Gossypol acetate, AT101, AT-101, AT101 cpd

PubChem CID:

227456

SMILES string:

CC1=C(C(=C2C(=C1)C(=C(C(=C2C=O)O)O)C(C)C)O)C3=C(C=C4C(=C3O)C(=C(C(=C4C(C)C)O)O)C=O)C.CC(=O)O

InChi Key:

NIOHNDKHQHVLKA-UHFFFAOYSA-N

AT-101

Probe Information

Target Details

Probe Details

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AT-101

Probe Information

Target Details

Probe Details

Supporting Organizations

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